In this rail-shooter game, you play in this retelling of Resident Evil 0's train derailment and Umbrella Training Facility, where you play either as Rebecca Chambers or Billy Coen; Resident Evil's mansion incident where Chris and Jill try to solve the case of murders in the Arklay Forest.  In the Resident Evil 3's Raccoon City virus outbreak where you play as Jill and try to get through the zombie and mutant monster infested city alive, or as Ada Wong who just recently parted with Leon Kennedy and must escape the city via helicopter by the time it leaves before the destruction of the city.  Lastly, Chris and Jill join a special forces team to fight what's left of Umbrella in Russia.  Little do they know, that Wesker also is in the area trying to defeat his rival, Sergei Vladimir and take down Umbrella once in for all.