During filming in South Africa, an improperly secured Humvee slid off of a rotating platform, crushing crew member Ricardo Cornelius against a wall. He was rushed to the hospital and placed on life support, but he died a few hours later. It was the film's second on-set accident, and the only fatal one. The film is dedicated to his memory.

A TV series was supposedly in the works following the release of this final Resident Evil film, but then the idea of a reboot film was eventually announced instead. Both ideas came to fruition, with a reboot film Resident Evil: Welcome to Raccoon City (2021), and a standalone Netflix original series simply called Resident Evil (2022). Both follow their own continuity and have no connection to the Paul W.S. Anderson films.

The film takes place three weeks after the events of Resident Evil: Retribution (2012), despite being released four years later. It is never revealed what became of Jill Valentine (Sienna Guillory), Ada Wong (Bingbing Li), Leon S. Kennedy (Johann Urb) and Becky (Aryana Engineer), who all survived the previous movie but are absent from this one, so it is implied that they all died off-screen during the battle of the White House (the novelization is more explicit in their fates). In reality, Engineer didn't return because she outgrew her role, Li had other commitments, and Guillory wasn't asked.

Stuntwoman Olivia Jackson was involved in a motorcycle crash during filming. The dangerous stunt involved her driving a motorcycle towards a camera mounted on a crane, while she wore no helmet as the shot required her not to. The crane malfunctioned and didn't move out of the way in time. Noticing this, she tried (and failed) to block it with her arm. She received several serious life threatening injuries including a twisted spine, broken discs, brain bleeding, shattered scapula, nerves torn, leaking cerebral fluid, degloved face (which is when facial skin is ripped off to reveal muscle tissue and teeth), shattered eye socket which had to be put together with tweezers, cheekbone shard stabbing her ear drum, fingers torn from her hand, an entire bone ripped out of her arm. Her left arm, which suffered these injuries, was injured so badly it had to be amputated. She was put into a medically induced coma for 17 days to perform all of the surgeries. Paul W.S. Anderson was so devastated by the accident that he nearly quit the project, while Milla Jovovich visited Jackson in the hospital and brought her flowers. Jackson sued (and won) the production company for the workplace injuries, as she was initially only compensated $33,000 for the injuries.

Milla's daughter Ever was originally only supposed to shoot for two days as the young Alicia, with no dialogue. However she was then asked to stand in for the Red Queen simply as a reference for the visual effects but was so good they decided to use her in the actual film. She ultimately had to learn more dialogue than anyone else in the movie.

Sienna Guillory announced on Twitter that she was never asked to join the project to reprise her role of Jill Valentine. She did however acknowledge thanks from all the fans for their support for her performance as the character.

Megan Charpentier had outgrown the role of the Red Queen, which she previously played in Resident Evil: Retribution (2012), and was recast with Milla Jovovich and Paul W.S. Anderson's real life daughter Ever Anderson in her feature film debut.

A number of YouTubers who were in Cape Town, South Africa, for a convention were given a chance to appear in the film as zombies.

Filming was originally scheduled to start in Fall 2013 for a September 12, 2014 release date. Filming was delayed when Milla Jovovich became pregnant with her and director Paul W.S. Anderson's second child.

With a domestic gross of only $26.8 million, this film was the lowest grossing film in the entire series. However, when you factor in the overseas markets, the film grossed a worldwide box office of $312 million, which means this film is actually the highest grossing Resident Evil film in the entire series, surpassing Resident Evil: Afterlife (2010), which had a worldwide total of $296 million.

Bingbing Li was due to reprise her role as Ada Wong but had to leave production before shooting started because she had committed to another movie in China.

The film sees the return of Ali Larter as Claire Redfield. The character was last seen in Resident Evil: Afterlife (2010). Larter was absent from Resident Evil: Retribution (2012) because she was pregnant at the time.

Ali Larter has confirmed that this film is indeed the final chapter in an interview with multiple media outlets such as IGN, Cinema Blend and more.

95% of this film was shot with a hand-held camera which the director controlled himself.

The outfit that Claire Redfield, Ali Larter's character, wears is the same outfit that was worn by Claire Redfield in the game Resident Evil: Revelations 2 (2015).

Wentworth Miller was unable to reprise his role as Chris Redfield due to scheduling conflicts with the new season of Prison Break (2005). The character was only in one film, Resident Evil: Afterlife (2010).

On the side of the army Hummer that Alice (Milla Jovovich) rides in the beginning of the film, the letters BSAA can be seen. This is short for Bioterrorism Security Assessment Alliance, which is the name of an anti-bioterrorism task force introduced in the game franchise in Resident Evil 5 (2009).

When Alice is driving to Racoon City, there's a brief shot of a Rayden bobble head from Mortal Kombat on the dashboard. Mortal Kombat is director Paul Anderson's first video game film adaptation.

The title card that accompanies Dr. James Marcus makes reference to the Arklay Mountains, which is where the first Resident Evil game took place.

The film did receive the best Rotten Tomatoes score and the highest gross of the Resident Evil series.

Lee Joon-gi, a Korean actor popular in his home country, makes his American feature film debut with this film, playing the Umbrella Corporation's Commander Lee.

Milla Jovovich is the only actor to appear in every single film of the series.

The only movie in the series not to feature any songs.

The film came out on January 27, 2017, three days after the release of the new installment of the video game series, Resident Evil 7: Biohazard (2017).

Aryana Engineer could not reprise her role as Becky as she had outgrown the role once production began and no longer looked the same age. Becky was written out of the film instead of having her recast.

The film was released almost 15 years after the first Resident Evil (2002) film.

Has the longest run-time out of all the films in the series, with 106 minutes. The second longest was the first film, with a length of 100 minutes.

The air intake for the hive, with the large fan blades, was actually a wind tunnel, similar to those used to test aircraft designs.

When Claire is trapped in the glass cell, she uses a lighter to ignite a fuse. Lighters are an important tool in many of the Resident Evil games.

The final day of filming took place December 10, 2015 in Belhar, South Africa.

The large winged creature that attacks Alice while she is leaving Washington is a Kipepeo, a bioweapon introduced in Resident Evil 5 (2009), although in that game, it is a Plagas mutant rather than a product from the T-virus.

The first Resident Evil film that failed to open at #1 at the domestic box office since the original Resident Evil (2002).

With this film, the Resident Evil franchise broke $1 billion at the global box office. It was the second horror franchise to gross $1 billion worldwide, after Alien.

The watch Alice wears in the movie is actually a fitness watch, the Garmin Vivofit.

Feature film debut of TV personality Rola.

The memories that Alicia Marcus uploads for Alice at the end of the movie are actually real life home videos of Ever Anderson (Red Queen/Young Alicia). As her father is the director Paul W.S. Anderson, and her mother is Milla Jovovich (Alice), it worked out perfect to use them in the movie. Also, a couple of the pictures can be seen on Milla's Instagram.

Though it's not her feature film debut, which was the independent film Around the Block (2013), this is Ruby Rose's second film and her first major Hollywood motion picture that received a worldwide theatrical release.

Alice is revealed to be a clone of Alicia Marcus, and is therefore also "related" to the Red Queen. Appropriately enough, the latter is played by Milla Jovovich's real-life first daughter in this film.

The makeup process to transform Milla Jovovich into the older Alicia Marcus took 4-5 hours to complete.

The first appearance of Dr. James Marcus (Mark Simpson) in the film series. Dr. Marcus is a character taken from the games: he is one of the discoverers of the T-Virus who was killed by Albert Wesker in Resident Evil Zero (2002), but most of the similarities end there. The Dr. Marcus from the game was a much older American scientist with no children, and one of the founders of Umbrella. His motives for inventing the T-Virus were simple vanity and scientific curiosity, and he ruthlessly sacrificed test subjects along the way to obtain his goals. He was finally killed on the orders of co-founder Ozwell Spencer (a character not in the movies) when he no longer served Umbrella's interests, but was resurrected as an enhanced being due to his own T-Virus. In the movie, it was Dr. Isaacs who gave the order, but this character never appeared in the games.

The large humanoid creature in the Hive that fights Alice and kills Razor is a Bloodshot, which were featured in the game Resident Evil 6 (2012).

The subplot with Claire's boyfriend Doc being revealed to be a spy working for Umbrella after he betrays Alice is based on a similar subplot found in the game Resident Evil: Revelations 2 (2015).

Mistakes

In Resident Evil: Extinction (2007) it is stated that Dr. Isaacs is under Albert Wesker commands, but in this new installment Isaacs is in charge and Albert Wesker is just an employee.

When Alice is driving to to Hive, and her car runs over a spike strip, and then under a tractor trailer which rips the roof off of the car - the next scene shows the car crashing into a telephone pole. The scene where it hits the pole, the roof is still on the car, next scene it's gone, then next scene it's back again with telephone pole wires landing on the car, and then it's gone again as Alice exits the car.

When Isaacs is picked up by the second group of tanks, there is a bait human being pulled behind, just barely ahead of the advancing horde. They stop for several minutes while they get Isaacs aboard, but nothing seems to happen to the bait human as he's seen later still being pulled by the tank.

At the beginning of the movie, Alice gives a history of the Umbrella Corporation. She says that the T-Virus was created by a Dr. Marcus for his daughter Alicia to prevent her rapid aging. This completely contradicts the story of Resident Evil: Apocalypse as this movie establishes the T-Virus as being created by Dr. Ashford for his daughter Angie. While the novelization explains that Dr. Ashford created the Virus at the behest of Dr. Marcus, this is never made clear in the film.

The Final Chapter supposedly takes place 10 years after the outbreak in Raccoon City, but this is impossible. Resident Evil (2002) takes place in 2002 with Resident Evil: Apocalypse (2004) taking place only a day, or at most a few days after the first. Resident Evil: Extinction (2007) takes place 5 years after the first outbreak putting the time line at 2007. Then Resident Evil: Afterlife (2010) takes place 18 months after Extinction placing it most likely in 2009. Then Resident Evil Retribution takes place directly after Afterlife and the Final Chapter takes place 3 weeks after Retribution. That would mean that only 6-7 years have passed since the outbreak in Raccoon City, not 10.

At the end of the air intake scene, Alice stares at the cc camera, but on the next take, on her screen image, she looks above it instead of staring right into it.

Alice has trouble starting a Humvee, however military Humvee (such as the one she is starting) are not, and never have been operated by turning a key into an ignition.

The survivors note a second wave of undead heading towards them. They look through a thermal scope at a huge blob of red (indicating the horde). The dead do not give off thermal energy and would not show up on a thermal scope.

Red Queen was able to kill Albert Wesker after Old Alice fired him, stating that the Red Queen was not able to kill Umbrella's employees, but in the first installment of the franchise Resident Evil (2002), the Red Queen went homicidal and killed every employee from The Hive. In Resident Evil Retribution, the Red Queen even tried to kill Ada Wong and Alice, but they were still Umbrella's workers.

When Alice meets the clone Isaacs in the Umbrella tank she states that she was the one who killed the original Isaacs, when in fact it was her clone that killed him using the laser grid.

The Reflecting Pool, the shallow pond which faces the Lincoln Monument, is refreshed by the National Park Service. Since the world has been destroyed it is likely that there would be no one to service the pond and therefore it would be dry. Furthermore, Alice would have become seriously ill after drinking from this stagnant pond, much less one in which a rotting T-Virus victim was hiding in.

When Alice arrives in Raccoon city, a scene shows the devastated city. On the right, a plane wreckage is seen with smoke rising. Considering the time interval between widespread of virus and the movie events, the plane crash would have happened years ago and the smoke would have ceased long before the movie takes place.

Young Alicia / Red Queen has a mole on her cheek. It keeps switching sides.

There is no way that the "real" Isaacs could catch up to Alice and catch the vial of Anti-virus when she drops it. He would have had to be riding the elevator up from the Hive with Alice.

In the last scene of the film you can clearly see the completed One World Trade Center Tower in the background. In the first 3 movies in the series it is specified that the T-Virus Outbreak occurred in 2002 and much of the world population was wiped out in that year. The tower should not exist.

The White Queen explains in Resident Evil: Extinction (2007) that Alice's blood could potentially be used as a cure for the T-Virus because she is resistant to its negative effects and bonded with it. This plot point is never mentioned again, nor does it seem to be connected to the airborne anti-virus that is a part of this film's plot, which is established to be guaranteed to kill anything infected with the T-Virus.

Dr. Isaac's clone gets his hand cut off. The stump gets covered with an elastic material. The shape of a fist is clearly visible beneath it.

As revealed in this film, Alicia Marcus was who the T-Virus was invented for in the first place, to cure her progeria. This calls into question the plot of Resident Evil: Extinction (2007), where Isaacs keeps cloning Alice to figure out why the T-Virus bonded with her so well. Wouldn't it be fairly obvious to him and the rest of Umbrella that the reason why it bonded with her so well was because the T-Virus was designed for Alicia in the first place? Alice is a genetic copy of her after all, biologically identical.

The bag left by the original team that entered the Hive in the first movie shows no wear or dust from being left in the same position for 10 years when the Laser Grid hallway is covered in muck.

Isaacs had James Marcus killed so that he could take over Umbrella, but yet leaves his daughter Alicia unharmed for some reason. Given that she is his daughter, and therefore an heir to the Umbrella Corporation (which Alicia even tells Isaacs that she owns 50% of the company), there is no conceivable reason for why he should let her live, because she could potentially jeopardize his plans and everything he's working for, which is exactly what happens.

With this film revealing that the T-Virus outbreak was completely intentional on Isaacs' part to end the world and rebuild it in Umbrella's image, this directly contradicts the events of the first film, where the T-Virus outbreak was quite clearly orchestrated by Spence so that he could escape with a few vials of the virus and sell them to the highest bidder on the black market. Unless Spence was working with Issacs, and there's no indication of this since Isaacs and Wesker never mention him, then these motivations don't match up in this film's canon. Spence only had three possible futures if he knew about Umbrella's plan to end the world, either live out the apocalypse with other survivors, die and become a zombie, or become frozen with Umbrella's high elite and wait it out, and in all of those scenarios, money would mean absolutely nothing.

This film heavily implies that the airborne anti-virus that Isaacs had planned to release to cleanse the world of the T-Virus in order to repopulate was not a new invention. This brings into question on why the Red Queen never mentioned its existence in the previous films, or any other Umbrella executive for that matter. Furthermore, why did Umbrella only develop one vial if they were planning to cleanse the whole world with it? As Alice explains in the ending, the anti-virus is spread by wind, so it could take years for it to reach every corner of the earth.

Dr Isaacs and Wesker becomes suspicious of Alice knowing of airborne antivirus. And yet, they bring her, who is a strong adversary, to the facility where the antivirus is held. It would be wiser to take her further to prevent her to reach the cure within time.

Isaacs reveals that his plan was to intentionally start the T-Virus outbreak to end the world, so that he and the rest of Umbrella can rebuild it in their own image while leaving the world's infrastructures intact. This directly contradicts the events of Resident Evil: Extinction (2007), where Alice explains in the opening narration that the T-Virus is effectively killing the earth, by drying up bodies of water and forests, and reducing continents to barren wastelands.

The real Dr. Alexander Isaacs is immediately unfrozen by the time Alice and the group get to the hive, yet he somehow knows that Doc is the mole or that even Alice exists, despite the implication being that he was frozen long before the events of the film to wait out the apocalypse.

To prevent Alice and company from entering the hive, Wesker orders the release of cerberus. When they survive the creatures onslaught and make it to the front of the Hive's gate, only then he give the order to close it down. We see the huge and slow blast doors closing, slow enough that the protagonists just walk between them. If he had ordered to shut down the gate just at the beginning, Alice and friends would not be able to enter the Hive in the first place.

Alice detonating a bomb inches away from the vial of anti-virus that is in Isaacs' coat pocket is extremely careless, as it could have easily destroyed it and everything she was trying to protect.

If Isaacs was trying to kill Alice in the laser hallway, why didn't he use the inescapable grid laser pattern that has been used in previous films to kill people? She would not have been able to dodge it.

To drive the undead away, Alice and friends tie an enemy soldier to the back of the vehicle and let it go. The zombies begin to chase the bait, but none attack the 4 or 5 people who sent the bait.

Claire Redfield scolds Alice for trusting the Red Queen so easily when she tells her about the airborne anti-virus. This brings into question on how Claire even knows who the Red Queen is. Before this film, the two never met each other and Alice never mentioned her to Claire.

After Abigail gets sucked into the turbine & killed why didn't Wesker just keep it on, they could only hold on for so long & he was watching them on the monitors, why did he shut it off before they all could get sucked in & killed.

After releasing the female bait, Dr Isaacs orders to shoot her when she's close to the gate, yet he does not order to shoot the two defenders at the gate, just a few feet further than the bait.

Alice takes a motorcycle for her escape. The motorcycle, though not a pure adventure bike, is a dual-sport BMW bike which can also ride in mild rough terrain. For her, it would be easier to get off the road and getting out of Umbrella vehicle's weapons trajectory.