Synopsis

It's been a few years since the incident at Raccoon City involving a virus that plagued the city, turning the residents into flesh-eating zombies. Within these few years, the T-Virus had consumed the United States and eventually the world.  The virus exterminated the most of hum and animal life, and plant life.  The whole world of nature had dried up, withered away and died, leaving the world a wasteland of death, leaving some survivors. 

Project Alice is completely on her own, riding a motorcycle in a desert wasteland trying to stay alive, looking for food and resources to keep herself going.  She makes a stop at a former radio station where there's a corrupt family of survivors that attacks her, unleashes zombie dogs on Alice, which she fights off, and the family and collects new weapons to take on her journey.

Meanwhile, a convoy, lead by Raccoon City survivors Carlos Olivera, Claire Redfield, LJ and some others travel through the Nevada desert also looking for ways of staying alive together.  Eventually, the convoy meets up with Project Alice, and Alice sticks around and joins them as they try to figure out a plan and route to get to Alaska, where the infection may or may not of reached yet.

While Alice and the convoy go off to find resources, the sinister underground Umbrella Corporation has been experimenting with genetic clones of Project Alice as a way to make a cure to the T-Virus infection, including using already dead zombies as lab experiments.  Dr. Issacs also tries to locate the real Project Alice, thinking her blood hold the key to the cure.

While traveling together to ruined Las Vegas to get gas and supplies, a metal container containing zombies was left in their way as a "gift" from Umbrella.  The zombies attacked, leaving some of the survivors dead.  Alice and the convoy separate via Umbrella helicopter where they leave for Alaska, while Alice goes underground to stop Dr. Issacs, only to find a bunch of clones of her and a Dr. Issacs infected into a Tyrant monster.  She fights the Tyrant Issacs leaving him destroyed in the laser chamber that diced his body.

Meanwhile, in Tokyo, in another Umbrella facility, Chairman Albert Wesker is given a stern waring from Project Alice via tele hologram that she's coming for him and she'll be bringing her clone friends.