This is the first Resident Evil not to mention or reference the Umbrella Corporation in any way.

Leon is only half joking during his interrogation. He truly did get screwed out of his vacation and Americans can take guns with them on vacation if they're hunting.

The codenames Leon and his contacts use from The Wizard of Oz.  Leon's codename is Tin Man.

Leon obviously doesn't care what his superiors think, as he goes rogue the moment he's told they decided to pull out of the fight.

This was Robin Sachs' final film before his death on February 1, 2013 at the age of 61.  He died of heart failure.

Svetlana has a burn on her back.

Leon is not happy to see the Plaga again. He was unwillingly a host to one and nearly became converted when he was in Spain searching for the president's missing daughter Ashley Graham.

JD caused the Plaga to attack the church by not being careful when he released Leon from being captured.

Dominant Plaga can control other creatures created by viruses. Like the Lickers.

Leon is the only character to appear in every CGI Resident Evil movie. As of 2026 this marks the only appearance of Ada Wong in a CGI Resident Evil movie. Ada and Leon regularly crossed paths in almost all of his appearances in the video games.

Mistakes