Synopsis

The U.S. president's daughter has been kidnapped and taken to a secluded village in Spain.  Agent Leon S. Kennedy is assigned by president to locate his missing daughter, where he finds the mysterious village, but there's something not right with the locals. It's learned that the villagers and others in the region are part of a cult called the Los Illuminatos, which is controlled by Osmund Saddler that used a Las Plagas parasite to infect them all and controls them.

His journey has him find and lose Ashely (the U.S. president's daughter) searching the village, Salazar Castle and a military island base.  Leon also has encounters with an old ally, turned enemy (Jake Krauser) and must defeat him because he's working for Saddler himself.